Cefaclor

• Description:

  Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3) . Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H317, H334

• Target:

  5-HT Receptor; Antibiotic; Bacterial; Penicillin-binding protein (PBP)

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; GPCR/G Protein; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Cefaclor.html

• Purity:

  99.61

• Solubility:

  DMSO : 18.5 mg/mL (ultrasonic; warming) |H2O : 3.85 mg/mL (ultrasonic)

• Smiles:

  O=C (C (N12) =C (Cl) CS[C@]2 ([H]) [C@H] (NC ([C@H] (N) C3=CC=CC=C3) =O) C1=O) O

• Molecular Formula:

  C15H14ClN3O4S

• Molecular Weight:

  367.81

• Precautions:

  H317, H334

• References & Citations:

  [1]Joo MK, et al. Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice. Sci Rep. 2023 Sep 19;13 (1) :15529. |[2]Li M, et al. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34 (4) :547-55. |[3]Yoo HS, et al. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei Med J. 2014 Nov;55 (6) :1473-83. |[4]Neu HC, et al. Cefaclor: in vitro spectrum of activity and beta-lactamase stability. Antimicrob Agents Chemother. 1978 Apr;13 (4) :584-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  MUC4; β-lactam

• CAS Number:

  53994-73-3