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PYR01

CAT: 0804-HY-153225-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153225-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PYR01 is a non-nucleoside reverse transcriptase inhibitor and a killing activator targeting HIV infected cells. PYR01 has cytokilling and antiviral properties of HIV-1 infection with the IC50 values of 27.5nM and 39.7nM, respectively. PYR01 leads to selective cytotoxicity by promoting HIV-1 Gag-Pol dimerization and HIV-1 protease intracellular activation. PYR01 can be used in the study of HIV[1].
CAS Number
2560576-15-8
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pyr01.html
Purity
99.32
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CC1=C(C#N)C=C(C(F)F)C=C1OC2=C(C(F)(F)C(F)F)N=CN(CC3=CC(F)=CNC3=O)C2=O
Molecular Formula
C21H13F7N4O3
Molecular Weight
502.34
References & Citations
[1]Carl J Balibar, et al. Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1. Sci Transl Med. 2023 Feb 22;15 (684) :eabn2038.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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