TSLP

CAT: 0209-100-304SSize: 2 µgDry Ice: NoHazardous: No
CAT#:0209-100-304SSize:2 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR) . Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML) -derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c (+) dendritic cells (DCs) . TSLP activated DCs primed naïve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa protein consisting of 132 amino
Synonyms
TSLP
NCBI Gene ID
85480
UniProt
Q969D9
Accession Number
NP_149024.1
Accession Number mRNA
NM_033035
Chromosomal Location
5q22.1
Reactivity
Human
Cross Reactivity
Mouse, Human
Sequence
MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGL WRRFNRPLLK QQ
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Data not available.
Length
132
Form
Lyophilized
Molecular Weight
15 kDa
Host or Source
E. coli

Related Products

CatalogName

Alternative Products

CatalogName
377645TSLP
048628TSLP (Schering patent TSLP) discontinued
EMk27537Monkey TSLP (TSLP) ELISA Kit
MBS154712-01TSLP and TSLP Receptor Detection Set
MBS6008603-01TSLP, CT (TSLP, Thymic stromal lymphopoietin)
MBS7124441-01TSLP Antibody
MBS201144-01Recombinant TSLP
DF8077-BPTSLP Peptide
32-6584-1TSLP Mouse
600317Human TSLP

Popular Products