TROP-2

• Description:

  Human TROP-2, also called tumor associated calcium signal transducer 2 (TACSTD2), gp50 and T16, is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It is related to EpCAM, also called TROP-1, gp40 and KSA. A study of these two genes suggests that TROP-2 was generated through the retropositioning of the EpCAM gene. TROP-2 and EpCAM share approximately 49% amino acid sequence identity and approximately 67% similarity. Mature human and mouse TROP-2 share 80% amino acid identity.

• Synonyms:

  TACSTD2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1

• NCBI Gene ID:

  4070

• UniProt:

  P09758

• Accession Number:

  NP_002344

• Accession Number mRNA:

  NM_002353

• Chromosomal Location:

  1p32

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Human recombinant TROP-2

• Clone:

  (#49D6)

• Applications:

  WB, FC

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG2A