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TNF receptor type I, soluble

CAT: 0209-100-118SSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0209-100-118SSize:5 µg
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Description
TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFkB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. Recombinant human sTNFR1 is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFR1 protein.
Synonyms
TNFRSF1A; FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55
NCBI Gene ID
7132
UniProt
P19438
Accession Number
NP_001056.1
Accession Number mRNA
NM_001065.3
Chromosomal Location
12p13.2
Reactivity
Human
Cross Reactivity
Mouse, Rat, Human
Sequence
MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & FPLC analyses
Bioactivity
Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-α, is 0.05 µg/ml.
Length
162
Form
Lyophilized
Molecular Weight
18.3 kDa
Host or Source
E. coli

UniProtKB · P19438

Tumor necrosis factor receptor superfamily member 1A

TNR1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19438
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFRSF1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K4X3, B2RDE4, B3KPQ1, B4DQB7, B4E309, B5M0B5, D3DUR1, Q9UCA4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

AmyloidosisDisease variant

Biological process

ApoptosisHost-virus interaction

Cellular component

Cell membraneGolgi apparatusMembraneSecreted

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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