TMEFF1

• Description:

  Transmembrane Protein with EGF-like and two Follistatin-like domains 1 (TMEFF1) also known as tomoregulin-1 is a type I transmembrane glycoprotein. TMEFF1 contains two follistatin modules and an EGF domain in its extracellular domain, a transmembrane domain and a short cytoplasmic tail. The extracellular domain of TMEFF1 can be released as a soluble protein. TMEFF1 is predominantly expressed in brain, but is downregulated in brain neoplasms. TMEFF1 selectively regulates nodal but not activin signaling through direct binding to the nodal co-receptor, Cripto.

• Synonyms:

  TMEFF1; TR-1; H7365; C9orf2; CT120.1

• NCBI Gene ID:

  8577

• UniProt:

  Q8IYR6

• Accession Number:

  NP_003683.2

• Accession Number mRNA:

  NM_003692.4

• Chromosomal Location:

  9q31

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  EC domain of human TMEFF1 (also called Tomoregulin-1)

• Clone:

  (#7S12)

• Applications:

  WB

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG2