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TGF-beta2

CAT: 0209-101-M723Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M723Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TGF-beta 2 belongs to the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t (1;7) (q41; p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms
Transforming growth factor beta-2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; Polyergin
NCBI Gene ID
7042
UniProt
P61812
Accession Number
NP_001129071.1
Accession Number mRNA
NM_001135599.2
Chromosomal Location
1q41
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human TGF-beta 2
Clone
(#6M28)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
Western Blot: 1:1000 - 2000; IHC (Paraffin) : 1:100 - 500.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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