TGF-alpha Recombinant Protein

TGF-alpha Recombinant Protein

• Description: TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces transformation anchorage independence in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant human TGF-α is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.
• Synonyms: TGFA; TFGA
• CAS Number: 9000-83-3
• NCBI Gene ID: 7039
• UniProt: P01135
• Accession Number: NP_003227.1
• Accession Number mRNA: NM_003236
• Gene Location: 2p13
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Chicken, Mouse, Rat, Human, Horse
• Sequence: VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA
• Detection Range: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 50
• Form: Lyophilized
• Molecular Weight: 5.5 kDa
• Shipping Conditions: Room Temperature