TFF-3 Recombinant Protein

TFF-3 Recombinant Protein

• Description: The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation. Recombinant human TFF3 is a 13.2 kDa homodimeric protein consisting of two 59 amino acid chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
• Synonyms: TFF3; ITF; P1B; TFI
• CAS Number: 9000-83-3
• NCBI Gene ID: 7033
• UniProt: Q07654
• Accession Number: NP_0031217.3
• Accession Number mRNA: NM_003226
• Gene Location: 21q22.3
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF
• Detection Range: Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 μg/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 59
• Form: Lyophilized
• Molecular Weight: 13.2 kDa
• Shipping Conditions: Room Temperature