ROR2, soluble

CAT: 0209-S01-074SSize: 2 µgDry Ice: NoHazardous: No
CAT#:0209-S01-074SSize:2 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ROR2 is a signaling receptor for Wnt ligands that is known to play important roles in limb development, but having no essential roles known in adult tissues. Recent evidence has implicated ROR2 in mediating both canonical and non-canonical signaling pathways. ROR2 was initially found to be highly expressed in osteosarcoma and renal cell carcinomas, and has recently been found in an increasingly long list of cancers currently including melanoma, colon cancer, melanoma, squamous cell carcinoma of the head and neck, and breast cancer. In the majority of these cancer types, ROR2 expression is associated with more aggressive disease states, consistent with a role mediating Wnt signaling regardless of the canonical or non-canonical signal. Because of the pattern of tissue distribution, the association with high-risk diseases, and the cell surface localization of this receptor, ROR2 has been identified as a potential high value target for therapeutic development. However, the recent discovery that ROR2 may function through non-kinase activities challenges this strategy and opens up opportunities to target this important molecule through alternative means.
Synonyms
Neurotrophic tyrosine kinase, receptor-related 2
NCBI Gene ID
4920
UniProt
Q01974
Accession Number
NP_004551.2
Accession Number mRNA
NM_004560.3
Reactivity
Human
Cross Reactivity
Human
Sequence
EVEVLDPNDP LGPLDGQDGP IPTLKGYFLN FLEPVNNITI VQGQTAILHC KVAGNPPPNV RWLKNDAPVV QEPRRIIIRK TEYGSRLRIQ DLDTTDTGYY QCVATNGMKT ITATGVLFVR LGPTHSPNHN FQDDYHEDGF CQPYRGIACA RFIGNRTIYV DSLQMQGEIE NRITAAFTMI GTSTHLSDQC SQFAIPSFCH FVFPLCDARS RTPKPRELCR DECEVLESDL CRQEYTIARS NPLILMRLQL PKCEALPMPE SPDAANCMRI GIPAERLGRY HQCYNGSGMD YRGTASTTKS GHQCQPWALQ HPHSHHLSST DFPELGGGHA YCRNPGGQME GPWCFTQNKN VRMELCDVPS CSPRDSSKMG HHHHHH
Assay Protocol
Centrifuge vial prior to opening. The lyophilized sROR2 is soluble in water and most aqueous buffers and should be reconstituted in water to a concentration not lower than 100 µg/ml.
Purity
> 98% by SDS-PAGE & Coomassie stain
Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized human sROR2 at 2 μg/mL (100 μL/well) can bind rhWnt5a.
Length
376
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Molecular Weight
50.0 kDa
Storage Conditions
Lyophilized samples are stable for greater than six months at –20°C to –70°C. Reconstituted sROR2 should be stored in working aliquots at -70°C.
Host or Source
Insect cells
N Terminal Sequence
EVEVL

Related Products

CatalogName
102-PA143ROR2
102-PA143SROR2
101-M620ROR2
S01-048-L1000ROR1, soluble
S01-048SROR1, soluble
S01-048ROR1, soluble
S01-048-L500ROR1, soluble
S01-048-L250ROR1, soluble
S01-008-L1000CD4, soluble
S01-050-L500CD23, soluble

Alternative Products

CatalogName
MBS692286-01Human ROR2, soluble
MBS8533539-01ROR2
BNUM1912-50ROR2 (ROR2/1912), 1mg/mL
BNUM1911-50ROR2 (ROR2/1911), 1mg/mL
BNUB1911-500ROR2 (ROR2/1911), 0.2mg/mL
BNUB1912-100ROR2 (ROR2/1912), 0.2mg/mL
NBP3-07601-20ugMouse Monoclonal ROR2 Antibody (ROR2/1911)
NBP3-07462-20ugMouse Monoclonal ROR2 Antibody (ROR2/1912)
MBS7120005-01ROR2 Antibody
MBS517538-01ROR2, Active

Popular Products