Resistin Recombinant Protein

Resistin Recombinant Protein

• Description: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin’s ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis. Recombinant rat Resistin is a 20.0 kDa disulfide-linked homodimeric protein composed of two 94 identical amino acid chains linked by a single disulfide bond.
• Synonyms: Retn
• CAS Number: 9000-83-3
• NCBI Gene ID: 246250
• UniProt: Q8K4J7
• Accession Number: NP_653342.1
• Accession Number mRNA: NM_144741
• Gene Location: 12p12
• Host: E. coli
• Origin Species: Rat
• Species Reactivity: Rat
• Sequence: PSMSLCPMDE AISKKINQDF SSLLPAAMKN TVLHCWSVSS RGRLASCPEG TTVTSCSCGS GCGSWDVRED TMCHCQCGSI DWTAARCCTL RVGS
• Detection Range: Data not available.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 97% by SDS-PAGE & HPLC analyses
• Length: 94
• Form: Lyophilized
• Molecular Weight: 20 kDa
• Shipping Conditions: Room Temperature