Prolactin

• Description :

  Prolactin, also known as mammotrophin, luterotropic hormone, and lutetropin, is a neuroendocrine hormone secreted by the pituitary gland. Its primary function is to promote and maintain lactation during pregnancy and suckling. In addition, Prolactin plays an immune-regulatory role by stimulating the activities of ornithine decarboxylase and protein kinase C, which are important for the proliferation, differentiation, and function of lymphocytes. Recombinant human Prolactin is a 23 kDa globular protein containing 200 amino acid residues.

• Synonyms :

  Mammotropin, Luterotropic hormone, Lutetropin

• NCBI Gene ID :

  5617

• UniProt :

  P01236

• Accession Number :

  NP_000939.1

• Accession Number mRNA :

  NM_000948

• Chromosomal Location :

  6p22.2-p21.3

• Reactivity :

  Human

• Cross Reactivity :

  Rat, Human

• Sequence :

  MLPICPGGAA RCQVTLRDLF DRAVVLSHYI HNLSSEMFSE FDKRYTHGRG FITKAINSCH TSSLATPEDK EQAQQMNQKD FLSLIVSILR SWNEPLYHLV TEVRGMQEAP EAILSKAVEI EEQTKRLLEG MELIVSQVHP ETKENEIYPV WSGLPSLQMA DEESRLSAYY NLLHCLRRDS HKIDNYLKLL KCRIIHNNNC

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to induce the proliferation of rat Nb2-11 cells in the concentration range of 0.1-1.0 ng/ml.

• Length :

  200

• Form :

  Lyophilized

• Molecular Weight :

  23 kDa

• Host or Source :

  E. coli