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PlGF

CAT: 0209-M30-020Size: 20 µgDry Ice: NoHazardous: No
CAT#: M30-020Size: 20 µg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family of growth factors. PlGF and VEGF share primary structural as well as limited amino acid sequence homology with the A and B chains of PDGF. All eight cysteine residues involved in intra and interchain disulfides are conserved among these growth factors. As a result of alternative splicing, three PlGF RNAs encoding monomeric human PlGF1, PlGF2 and PlGF3 isoform precursors containing 149, 179 and 219 amino acid residues, respectively, have been described. In normal mouse tissues, only one mouse PlGF mRNA encoding the equivalent of human PlGF2 has been identified. Mouse PlGF shares 65% amino acid identity with human PlGF2. The gene for PlGF has been mapped to mouse chromosome 12 and human chromosome 14. PlGF binds with high affinity to Flt1, but not to Flk1/KDR.
Synonyms
Pgf; PlGF; Plgf; AI854365; placental growth factor
NCBI Gene ID
18654
UniProt
P49764
Accession Number
NP_032853
Accession Number mRNA
NM_008827
Chromosomal Location
12 D; 12 39.0 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
ALSAGNNSTEVEVVPFNEVWGRSYCRPMEKLVYILDEYPDEVSHIFSPSCVLLSRCSGCCGDEGLHCVPIKTANITMQILKIPPNRDPHFYVEMTFSQDVLCECRPILETTKAERRKTKGKRKRSRNSQTEEPHP
Assay Protocol
Centrifuge vial prior to opening. The lyophilised PlGF is supplied in lyophilized form with carrier-protein (BSA) and can be reconstituted with 50mM acetic acid or PBS/water. This solution can be diluted into other buffered solutions or stored frozen for future use.
Purity
> 95% by SDS-PAGE
Bioactivity
Measured by its ability to bind to immobilized rh-sFlt-1 in a functional ELISA. Recombinant mouse PlGF can bind to immobilized rh-sFlt-1 (100 ng/well) with a linear range at 0.5 - 10 ng/mL.
Length
135/132
Form
Lyophilized
Buffer
25 mM Tris, 75 mM NaCl pH 8.5
Additives
BSA (50-fold)
Reconstitution
50 mM acetic acid
Molecular Weight
~40 kDa
Storage Conditions
The lyophilized mouse PIGF, though stable at room temperature, is best stored in working aliquots at -20°C to -70°C.
Host or Source
Insect cells
N Terminal Sequence
ALSAGNNSTE and AGNNSTE

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