PIN

• Description:

  Pin1 is a peptidylprolyl isomerase (PPI) that targets phosphorylated Ser or Thr residues followed by a Pro (S/TP) . Isomerization of phosphorylated Ser or Thr residues may alter protein confirmation and, subsequently, modify activity. Pin1 is overexpressed in many human breast cancers, and has been shown to modify numerous proteins including p53, NFκB, cJun, cyclin D1, and βcatenin.

• Synonyms:

  PIN1; DOD; UBL5

• NCBI Gene ID:

  5300

• UniProt:

  Q13526

• Accession Number:

  NP_006212.1

• Accession Number mRNA:

  NM_006221.3

• Chromosomal Location:

  19p13

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human PIN

• Clone:

  (#9S2)

• Applications:

  WB

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG1