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P16-INK4a-TAT

CAT: 0209-100-422SSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0209-100-422SSize:5 µg
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Description
P16-INK4a is a nuclear protein that regulates the cell cycle by inhibiting cyclin dependent kinase-4 (CDK4) and CDK6. p16-INK4a inhibits CDK activity by binding to the CDK molecules in a manner that interferes with their ability to interact with cyclin D. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of p16-INK4a steadily increases with age and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the p16-INK4a gene is frequently found in melanomas as well as in certain other types of cancer. P16-INK4a and other transcription factors have been introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other nuclear proteins into primary as well as transformed cells. Recombinant human p16-INK4a-TAT expressed in E. coli is a 18 kDa protein containing 167 amino-acid residues, including the 156 residues of full-length p16-INK4a and a 12-residue C-terminal TAT peptide (GYGRKKRRQRRR) .
Synonyms
Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase 4 inhibitor A, CDK4I, MTS-1, Multiple tumor suppressor 2
NCBI Gene ID
1029
UniProt
P42771
Accession Number
NP_478104.2
Accession Number mRNA
NM_058197.4
Chromosomal Location
9p21
Reactivity
Human
Cross Reactivity
Human
Label
TAT-Fusionprotein
Sequence
EPAAGSSMEP SADWLATAAA RGRVEEVRAL LEAGALPNAP NSYGRRPIQV MMMGSARVAE LLLLHGAEPN CADPATLTRP VHDAAREGFL DTLVVLHRAG ARLDVRDAWG RLPVDLAEEL GHRDVARYLR AAAGGTRGSN HARIDAAEGP SDIPDGYGRK KRRQRRR
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Data not available.
Length
167
Form
Lyophilized
Molecular Weight
18 kDa
Host or Source
E. coli

UniProtKB · P42771

Cyclin-dependent kinase inhibitor 2A

CDN2A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P42771
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDKN2A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A5X2G7, D3DRK1, G3XAG3, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeat

Biological process

Cell cycle

Cellular component

CytoplasmNucleus

Disease

Disease variantLi-Fraumeni syndromeTumor suppressor

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