NNT-1/BCSF-3 Recombinant Protein
CAT:
209-100-259S
Size:
2 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NNT-1/BCSF-3 Recombinant Protein
- Description: NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-beta) and induces tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM. Recombinant human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.
- Synonyms: CLCF1; CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
- CAS Number: 9000-83-3
- NCBI Gene ID: 23529
- UniProt: Q9UBD9
- Accession Number: NP_037378.1
- Accession Number mRNA: NM_013246
- Gene Location: 11q13.3
- Host: E. coli
- Origin Species: Human
- Species Reactivity: Chicken
- Sequence: MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF
- Detection Range: NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.
- Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
- Purity: > 98% by SDS-PAGE & HPLC analyses
- Length: 199
- Form: Lyophilized
- Molecular Weight: 22.4 kDa
- Shipping Conditions: Room Temperature