NLRP3

CAT: 0209-103-M549Size: 50 µgDry Ice: NoHazardous: No

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CAT#:0209-103-M549Size:50 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 and 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes. Mouse NLRP3 contains an N-terminal Pyrin domain (aa 1-91) followed by a Nacht region (aa 216-532), and seven LRRs (aa 739-988) . Within the sequence used as an immunogen, mouse NLRP3 shares 78% and 93% aa identity with human and rat NLRP3, respectively. Alternate splicing of mouse NLRP3 generates additional isoforms that lack either LRR2 and 3, LRR 6 and 7, or LRR4-9.

Synonyms

NACHT, LRR and PYD domains-containing protein 3, Cold autoinflammatory syndrome 1 protein homolog, Cryopyrin, Mast cell maturation-associated-inducible protein 1, PYRIN-containing APAF1-like protein 1

NCBI Gene ID

216799

UniProt

Q8R4B8

Accession Number

NP_665826.1

Accession Number mRNA

NM_145827.3

Reactivity

Anti-Mouse

Cross Reactivity

Mouse

Target Antigen

Recombinant Mouse NLRP3

Clone

(#8B16)

Applications

WB, ICC

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Rat

Isotype

IgG2

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QY-E06005	Human NLRP3 Inflammasome (NLRP3)
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A4698-100	NLRP3-IN-2
BA6120-25	NLRP3-IN-18

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