NCAM-L1

• Description:

  The cell adhesion molecule NCAM-L1 (or L1CAM) is an immunoglobulin superfamily adhesion molecule that is critical for neural development. Two alternatively spliced isoforms of L1CAM have been described. The full-length signaling isoform is expressed exclusively in neurons. The second non-neuronal variant lacks a five-residue extracellular sequence and a four residue cytoplasmic sequence that is important in signaling and clathrin-mediated endocytosis.

• Synonyms:

  L1CAM; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1

• NCBI Gene ID:

  3897

• UniProt:

  P32004

• Accession Number:

  NP_000416.1

• Accession Number mRNA:

  NM_000425.4

• Chromosomal Location:

  Xq28

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Human recombinant protein of NCAM-L1 EC domain

• Clone:

  (#1J36)

• Applications:

  WB

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG1