MIP-3 (CCL23)

• Description:

  MIP-3 is a CC chemokine that signals through the CCR1 receptor. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but does not chemoattract activated lymphocytes. Additionally, MIP-3 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. Recombinant human MIP-3 is an 11.3 kDa protein containing 99 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

• Synonyms:

  CCL23; CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; CK-BETA-8

• NCBI Gene ID:

  6368

• UniProt:

  P55773

• Accession Number:

  NP_005055

• Accession Number mRNA:

  NM_005064

• Chromosomal Location:

  17q12

• Reactivity:

  Human

• Cross Reactivity:

  Human, Mouse

• Sequence:

  RVT kDaETEF MMSKLPLENP VLLDRFHATS ADCCISYTPR SIPCSLLESY FETNSECSKP GVIFLTKKGR RFCANPSDKQ VQVCMRMLKL DTRIKTRKN

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human T cell population using a concentration of 10-50 ng/ml.

• Length:

  99

• Form:

  Lyophilized

• Molecular Weight:

  11 kDa

• Host or Source:

  E. coli