Mouse Anti-Human MIP-1 alpha Monoclonal Antibody

Mouse Anti-Human MIP-1 alpha Monoclonal Antibody

• Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant human MIP-1α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
• Synonyms: CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
• CAS Number: 9007-83-4
• NCBI Gene ID: 6348
• UniProt: P10147
• Accession Number: NP_002974.1
• Accession Number mRNA: NM_002983
• Gene Location: 17q12
• Host: Mouse
• Origin Species: Human
• Species Reactivity: Human
• Target Antigen: Recombinant Human MIP-1 alpha
• Isotype: IgG1 κ
• Validated Applications: ELISA, N
• Purification Method: Protein G chromatography
• Form: Lyophilized from PBS
• Buffer: PBS
• Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.