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MIA

CAT: 0209-102-P239Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-P239Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3) -like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds. .
Synonyms
MIA; CD-RAP
NCBI Gene ID
8190
UniProt
Q16674
Accession Number
NP_006524
Accession Number mRNA
NM_006533
Chromosomal Location
19q13.32-q13.33
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant Human MIA
Clone
Rabbit IgG
Applications
ELISA, WB
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Rabbit

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