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MesP1

CAT: 0209-300-060Size: 10 µgDry Ice: NoHazardous: No
CAT#: 300-060Size: 10 µg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is required for cardiac morphogenesis. It was shown that MesP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells. Electrophysiological analysis showed all subtypes of cardiac ES-cell differentiation. MesP1 overexpression and knockdown experiments revealed a prominent function of MesP1 in a gene regulatory cascade, causing Dkk-1-mediated blockade of canonical Wnt-signalling. Independent evidence from ChIP and in vitro DNA-binding studies, expression analysis in wild-type and MesP knockout mice, and reporter assays confirm that Dkk-1 is a direct target of MesP1.
Synonyms
MESP1; bHLHc5
NCBI Gene ID
55897
UniProt
Q9BRJ9
Accession Number
NP_061140.1
Accession Number mRNA
NM_018670.3
Chromosomal Location
15q26.1
Reactivity
Human
Cross Reactivity
Human
Sequence
MAQPLCPPLSESWMLSAAWGPTRRPPPSDKDCGRSLVSSPDSWGSTPADSPVASPARPGTLRDPRAPSVGRRGARSSRLGSGQRQSASEREKLRMRTLARALHELRRFLPPSVAPAGQSLTKIETLRLAIRYIGHLSAVLGLSEESLQRRCRQRGDAGSPRGCPLCPDDCPAQMQTRTQAEGQGQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK
Assay Protocol
Human MesP1 should be reconstituted in sterile water to a concentration of 0.1 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
Purity
> 95% by SDS-PAGE
Bioactivity
Testing in progress.
Length
268
Form
Lyophilized
Buffer
0.5X PBS
Reconstitution
Water
Molecular Weight
34 kDa
Storage Conditions
The lyophilized human MesP1, though stable at room temperature, is best stored desiccated below 0°C. Freeze/thaw cycles will result in significant loss of activity.
Host or Source
Insect cells

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