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MCAM

CAT: 0209-101-M563Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M563Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Melanoma Cell Adhesion Molecule (MCAM) /CD146 is a surface antigen on metastatic human melanoma cells originally called MUC18 or A32. The 113 kDa glycoprotein is a member of the immunoglobulin superfamily that shows significant homology to several cell adhesion molecules, notably N-CAM. MCAM/CD146 is also identical to the endothelial cell antigen S-Endo. In addition to melanoma and endothelial cells, MCAM/CD146 is expressed on smooth muscle cells, cerebellar cortex, trophoblasts and activated T cells. MCAM/CD146 is also expressed on a variety of malignant cell types including: vascular and smooth muscle tumors gliomas and neuroblastomas, prostate tumors, and in tumors arising from hematologic malignancies. As a proposed adhesion receptor, MCAM/CD146 may have an important role during tumor invasion and metastasis.
Synonyms
MCAM; CD146; MUC18
NCBI Gene ID
4162
UniProt
P43121
Accession Number
NP_006491.2
Accession Number mRNA
NM_006500.2
Chromosomal Location
11q23.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant protein of MBL-2.
Clone
(#4H55)
Applications
WB, FC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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