MANF

CAT: 0209-100-136Size: 25 µgDry Ice: NoHazardous: No

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CAT#:0209-100-136Size:25 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human MANF is an 18.1 kDa protein consisting of 158 amino acids including 8 cysteine residues.

Synonyms

MANF; ARP; ARMET

NCBI Gene ID

7873

UniProt

P55145

Accession Number

NP_006001.3

Accession Number mRNA

NM_006010.4

Chromosomal Location

3p21.1

Reactivity

Human

Cross Reactivity

Human

Sequence

LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & HPLC analyses

Bioactivity

Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml.

Length

158

Form

Lyophilized

Molecular Weight

18.1 kDa

Host or Source

E. coli

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cyt-141-01	MANF
cyt-133-01	MANF, His
391292	MANF discontinued
MBS7128420-01	MANF Antibody
MBS692051-01	Human MANF
OM297634-01	MANF Rat
4347P	MANF Peptide
GTR18984859-01	MANF Protein

MANF

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