Rabbit Anti-Mouse Lyve-1 Polyclonal Antibody

Rabbit Anti-Mouse Lyve-1 Polyclonal Antibody

• Description: LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
• Synonyms: Lyve1; Xlkd1; Lyve-1; Crsbp-1; 1200012G08Rik
• CAS Number: 9007-83-4
• NCBI Gene ID: 114332
• UniProt: Q8BHC0
• Accession Number: NP_444477
• Accession Number mRNA: NM_053247
• Gene Location: 7; 7F2
• Host: Rabbit
• Origin Species: Mouse
• Species Reactivity: Mouse
• Target Antigen: Recombinant Mouse soluble Lyve-1 (RT#S01-026)
• Clone: Rabbit IgG
• Validated Applications: WB, IHC (C), IF, FC
• Purification Method: Protein-A purified
• Detection Range: Western Blot: use at 2-5 µg/ml; FACS: use at 3-10 µg/ml; IF/IHC: applicable with cryo-sections.
• Form: Lyophilized
• Buffer: PBS
• Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.