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LIGHT

CAT: 0209-M10-076Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0209-M10-076Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8 tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NFkB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues.
Synonyms
Tnfsf14; LTg; HVEML; LIGHT; Ly113; HVEM-L; LIGHT; tumor necrosis factor (ligand) superfamily, member 14
NCBI Gene ID
50930
UniProt
Q9QYH9
Accession Number
NP_062291
Accession Number mRNA
NM_019418
Chromosomal Location
17; 17 D-E1
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANASLIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ LSGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSSRVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FMV
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its cytotoxic effecton HT-29 cells (human colon adenocarcinoma cells) in the presence of human IFN-gamma.
Length
183
Form
Lyophilized
Molecular Weight
20.1 kDa
Host or Source
E. coli

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