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Legumain

CAT: 0209-101-M801Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M801Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Legumain is a protein that in humans is encoded by the LGMN gene. This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
Synonyms
Legumain, Asparaginyl endopeptidase, Protease, cysteine 1
NCBI Gene ID
5641
UniProt
Q99538
Accession Number
NP_001008530.1
Accession Number mRNA
NM_001008530.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant Human Legumain
Clone
(#46I3)
Applications
E, WB
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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