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LAP/ TGF beta 1

CAT: 0209-101-M546Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M546Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5) . The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.
Synonyms
TGFB1; CED; LAP; DPD1; TGFB; TGFbeta
NCBI Gene ID
7040
UniProt
P01137
Accession Number
NP_000651.3
Accession Number mRNA
NM_000660.4
Chromosomal Location
19q13.2; 19q13.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human LAP TGF beta1
Clone
(#6G14)
Applications
WB, N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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