KIR2DS4

• Description :

  The KIR gene family currently consists of 15 gene loci (KIR2DL1, KIR2DL2/L3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1/S1, KIR3DL2, KIR3DL3 and two pseudogenes, KIR2DP1 and KIR3DP1) encoded within a 100-200 Kb region of the Leukocyte Receptor Complex (LRC) located on chromosome 19 (19q13.4) . The LRC constitutes a large, 1 Mb, and dense cluster of rapidly evolving immune genes which contains genes encoding other cell surface molecules with distinctive Ig-like extra-cellular domains. These genes include, from centromere to telomere, Leukocyte Immunoglobulin-like Receptors (LILR) and Leukocyte-Associated Immunoglobulin-like Receptors (LAIR), FcGammaR as well as the Natural cytotoxicity-triggering Receptor 1 (NCR1) . In addition the extended LRC contains genes encoding the Sialic acid binding Immunoglobulin-like Lectins (SIGLEC) and the CD66 family members such as the carcino-embryonic antigen (CEA) genes as well as the genes encoding the transmembrane adaptor molecules DAP10 and DAP12.

• Synonyms :

  KIR2DS4; KKA3; KIR1D; NKAT8; CD158I; KIR412

• NCBI Gene ID :

  3809

• UniProt :

  P43632

• Accession Number :

  NP_036446.3

• Accession Number mRNA :

  NM_012314.3

• Chromosomal Location :

  19q13.4

• Reactivity :

  Anti-Human

• Cross Reactivity :

  Human

• Target Antigen :

  Human recombinant KIRDS4

• Clone :

  (#2G42)

• Applications :

  WB, FC

• Purification Method :

  Protein G chromatography

• Assay Protocol :

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  PBS

• Storage Conditions :

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source :

  Mouse

• Isotype :

  IgG2