KIR

• Description:

  The KIR gene family currently consists of 15 gene loci (KIR2DL1, KIR2DL2/L3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1/S1, KIR3DL2, KIR3DL3 and two pseudogenes, KIR2DP1 and KIR3DP1) encoded within a 100-200 Kb region of the Leukocyte Receptor Complex (LRC) located on chromosome 19 (19q13.4) . The LRC constitutes a large, 1 Mb, and dense cluster of rapidly evolving immune genes which contains genes encoding other cell surface molecules with distinctive Ig-like extra-cellular domains. These genes include, from centromere to telomere, Leukocyte Immunoglobulin-like Receptors (LILR) and Leukocyte-Associated Immunoglobulin-like Receptors (LAIR), FcGammaR as well as the Natural cytotoxicity-triggering Receptor 1 (NCR1) . In addition the extended LRC contains genes encoding the Sialic acid binding Immunoglobulin-like Lectins (SIGLEC) and the CD66 family members such as the carcino-embryonic antigen (CEA) genes as well as the genes encoding the transmembrane adaptor molecules DAP10 and DAP12.

• Synonyms:

  GEM; KIR; CD158; Kiniogen

• NCBI Gene ID:

  2669

• UniProt:

  P55040

• Accession Number:

  NP_005252.1

• Accession Number mRNA:

  NM_005261.3

• Chromosomal Location:

  8q13-q21

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Human recombinant KIR

• Clone:

  (#11G25)

• Applications:

  WB

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG2