Mouse Anti-Human Integrin beta 2 Monoclonal Antibody

Mouse Anti-Human Integrin beta 2 Monoclonal Antibody

• Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
• Synonyms: ITGB2; LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
• CAS Number: 9007-83-4
• NCBI Gene ID: 3689
• UniProt: P05107
• Accession Number: NP_000202.2
• Accession Number mRNA: NM_000211.3
• Gene Location: 21q22.3
• Host: Mouse
• Origin Species: Human
• Species Reactivity: Human
• Target Antigen: Recombinant Human Integrin beta2
• Isotype: IgG1
• Clone: (#4K41)
• Validated Applications: WB, FC
• Purification Method: Protein G chromatography
• Form: Lyophilized
• Buffer: PBS
• Reconstitution: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.