IL-17B Recombinant Protein

IL-17B Recombinant Protein

• Description: IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-alpha and IL-1beta from cells of the monocyte lineage. Recombinant human IL-17B is a 36.6 kDa disulfide-linked homodimer of two 161 amino acid polypeptide chains.
• Synonyms: IL17B; NIRF; IL-20; IL-17B; ZCYTO7
• CAS Number: 9000-83-3
• NCBI Gene ID: 27190
• UniProt: Q9UHF5
• Accession Number: NP_055258.1
• Accession Number mRNA: NM_014443
• Gene Location: 5q33.1
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F
• Detection Range: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng. Please Note: Results may vary with PBMC donors.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 161
• Form: Lyophilized
• Molecular Weight: 36.6 kDa
• Shipping Conditions: Room Temperature