IL-15

• Description:

  IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant rat IL-15 is a 13.5 kDa protein consisting of 115 amino acid residues.

• Synonyms:

  Il15; 19q11

• NCBI Gene ID:

  25670

• UniProt:

  P97604

• Accession Number:

  NP_037261.1

• Accession Number mRNA:

  NM_013129

• Chromosomal Location:

  19q11

• Reactivity:

  Rat

• Cross Reactivity:

  Human, Mouse, Rat

• Sequence:

  MNWIDVRYDL EKIESLIQFI HIDTTLYTDS DFHPSCKVTA MNCFLLELQV ILHEYSNMTL NETVRNVLYL ANSTLSSNKN VIESGCKECE ELEERNFTEF LQSFIHIVQM FINTS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 96% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 as determined by the dose-dependant stimulation of the proliferation of murine CTLL-2 cells is < 10 ng/ml, corresponding to a specific activity of > 1 x 105 units/mg.

• Length:

  115

• Form:

  Lyophilized

• Molecular Weight:

  13.5 kDa

• Host or Source:

  E. coli