IL-15

CAT: 0209-M10-022SSize: 2 µgDry Ice: NoHazardous: No
CAT#:0209-M10-022SSize:2 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant murine IL-15 is a 13.3 kDa protein consisting of 115 amino acid residues.
Synonyms
Il15; IL-15; AI503618
NCBI Gene ID
16168
UniProt
P48346
Accession Number
NP_032383.1
Accession Number mRNA
NM_008357
Chromosomal Location
8 C2; 8 38.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse, Rat
Sequence
MNWIDVRYDL EKIESLIQSI HIDTTLYTDS DFHPSCKVTA MNCFLLELQV ILHEYSNMTL NETVRNVLYL ANSTLSSNKN VAESGCKECE ELEEKTFTEF LQSFIRIVQM FINTS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 was determined by the stimulation of the proliferation of murine CTLL-2 cells is < 5.0 ng/ml, corresponding to a specific activity of > 2 x 105 units/mg.
Length
115
Form
Lyophilized
Molecular Weight
13.3 kDa
Host or Source
E. coli

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