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IL-15

CAT: 0209-100-053SSize: 2 µgDry Ice: NoHazardous: No
CAT#:0209-100-053SSize:2 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.
Synonyms
IL15; IL-15
NCBI Gene ID
3600
UniProt
P40933
Accession Number
NP_000576.1
Accession Number mRNA
NM_000585.4
Chromosomal Location
4q31
Reactivity
Human
Cross Reactivity
Monkey, Mouse, Human, Rat, Cow
Sequence
MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Length
114
Form
Lyophilized
Buffer
20 mM NaP pH 8.5
Molecular Weight
12.9 kDa
Host or Source
E. coli

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