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IGF-BP7 (Animal Free)

CAT: 0209-100-203-AFSize: 25 µgDry Ice: NoHazardous: No
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CAT#:0209-100-203-AFSize:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP7 is expressed in a wide range of normal human tissues, and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. It plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF-induced differentiation of skeletal myoblasts, without affecting IGF-induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF-independent mechanism, which causes a delay in the G1 phase of the cell cycle and increased apoptosis. Recombinant Human IGF-BP7 is a 26.4 kDa protein consisting of 256 amino acid residues.
Synonyms
IGFBP7; AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1
NCBI Gene ID
3490
UniProt
Q16270
Accession Number
NP_001544.1
Accession Number mRNA
NM_001553
Chromosomal Location
4q12
Reactivity
Human
Cross Reactivity
Human
Sequence
SSSDTCGPCE PASCPPLPPL GCLLGETRDA CGCCPMCARG EGEPCGGGGA GRGYCAPGME CVKSRKRRKG KAGAAAGGPG VSGVCVCKSR YPVCGSDGTT YPSGCQLRAA SQRAESRGEK AITQVSKGTC EQGPSIVTPP KDIWNVTGAQ VYLSCEVIGI PTPVLIWNKV KRGHYGVQRT ELLPGDRDNL AIQTRGGPEK HEVTGWVLVS PLSKEDAGEY ECHASNSQGQ ASASAKITVV DALHEIPVKK GEGAEL
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Length
256
Form
Lyophilized
Molecular Weight
26.4 kDa
Host or Source
E. coli

UniProtKB · Q16270

Insulin-like growth factor-binding protein 7

IBP7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16270
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IGFBP7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IBP-7, IGF-binding protein 7, IGFBP-7
EC number
—
Processing
Precursor
Secondary accessions
B4E1N2, B7Z9W7, Q07822, Q53YE6, Q9UCA8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingRNA editing

Biological process

Cell adhesion

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Growth factor binding

Domain

Immunoglobulin domainSignal

Cellular component

Secreted

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HY-P700093AF-01Animal-Free IGF-I/IGF-1, Human (His)
HY-P700185AF-01Animal-Free IGF-II, Mouse (His)
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