IGF-BP5

• Description:

  IGFBP5 is expressed by fibroblasts, myoblasts and osteoblasts, making it the predominant IGFBP found in bone extracts. IGFBP5 has a strong affinity for hydroxyapatite, allowing it to bind to bone cells. When bound to extracelluar matrix, IGFBP5 is protected from proteolysis and potentiates IGF activity, but when it is soluble, IGFBP5 is cleaved to a biologically inactive 21 kDa fragment. Mouse, human and rat IGFBP5 share 97% identity.

• Synonyms:

  Igfbp5; IGFBP-5; AI256729; AW208790; IGFBP-5P

• NCBI Gene ID:

  16011

• UniProt:

  Q07079

• Accession Number:

  NP_034648.2

• Accession Number mRNA:

  NM_010518.2

• Chromosomal Location:

  1 C3; 1 36.1 cM

• Reactivity:

  Anti-Mouse

• Cross Reactivity:

  Mouse

• Target Antigen:

  Recombinant mouse protein of IGFBP-5

• Clone:

  (#12C23)

• Applications:

  WB

• Purification Method:

  Protein G/A chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2