RegisterLogin

IGF-BP3

CAT: 0209-100-199Size: 25 µgDry Ice: NoHazardous: No
CAT#:0209-100-199Size:25 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Human IGF-BP3, also known as growth-hormone-dependant binding protein, is 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in alpha-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.
Synonyms
IGFBP3; IBP3; BP-53
NCBI Gene ID
3486
UniProt
P17936
Accession Number
NP_001013416
Accession Number mRNA
NM_001013398
Chromosomal Location
7p13-p12
Reactivity
Human
Cross Reactivity
Human
Sequence
GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is ≤ 0.2 µg/ml in the presence of 15 ng/ml of human IGF-II.
Length
264
Form
Lyophilized
Molecular Weight
28.8 kDa
Host or Source
E. coli

Related Products

CatalogName
M60-118-L50IGF‑I / IGF-1 protein
600-163-L100IGF-2 / IGF-II Protein
M60-118-L1000IGF‑I / IGF-1 protein
600-163-L20IGF-2 / IGF-II Protein
M60-118-L20IGF‑I / IGF-1 protein
600-163-L1000IGF-2 / IGF-II Protein
100-203-L50IGF-BP7
100-203-L250IGF-BP7
M10-011-L100IGF-1
M10-011-L250IGF-1

Alternative Products

CatalogName
167878IGF-BP3, Recombinant, Human (Human IGF-BP3, IGF-BP3, IGFBP3, h-IGF-BP3, rh-IGF-BP3, recombinant human IGF-BP1, recombinant IGF-BP1, IGF) discontinued
MBS535722-01IGF BP3 antibody
MBS539422-01IGF BP3 protein
38-250IGF-BP3 Antibody
MBS692057-01Human IGF-BP3
RC216-12B3IGF-BP3, human
JOT-PR1044Recombinant Human IGF-BP3 ( rHuIGF-BP3 )
PR1044-01Recombinant Human IGF-BP3 (rHuIGF-BP3)
HEGFP-0903Recombinant Human IGF BP3
38-153IGF-BP3 Antibody (biotin)

Popular Products