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GDF-3 (Animal Free)

CAT: 0209-100-179S-AFSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0209-100-179S-AFSize:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia that characterizes Type 2 diabetes. Recombinant Human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.
Synonyms
GDF3; KFS3; MCOP7; MCOPCB6
NCBI Gene ID
9573
UniProt
Q9NR23
Accession Number
NP_065685.1
Accession Number mRNA
NM_020634
Chromosomal Location
12p13.1
Reactivity
Human
Sequence
AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/ml.
Length
114
Form
Lyophilized
Molecular Weight
26 kDa
Host or Source
E. coli

UniProtKB · Q9NR23

Growth/differentiation factor 3

GDF3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NR23
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GDF3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GDF-3
EC number
—
Processing
Precursor
Secondary accessions
Q8NEJ4
Protein keywords

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Molecular function

CytokineDevelopmental proteinGrowth factor

Cellular component

CytoplasmSecreted

Disease

Disease variantMicrophthalmia

Technical term

Proteomics identificationReference proteome

Domain

Signal

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