Furin

CAT: 0209-101-M746Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0209-101-M746Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Furin is a member of the proprotein convertase (PC) family, which belongs to the subtilisin superfamily of serine protease. As a cellular protease, Furin processes a variety of proproteins in secretory pathway compartments by cleaving after ArgXaaLys/ ArgArglike motifs, which usually reside at the end of the pro regions of these proproteins. Examples of the proprotein substrates are growth factors and receptors, extracellular matrix proteins, and other proteases. Furin has an essential role in embryogenesis and homeostasis and is implicated in various pathologies such as cancer, neurodegenerative diseases and anthrax. It is synthesized as a 794 amino acid type I transmembrane protein precursor with a signal peptide (residues 124), a pro region (residues 25-107), which play a crucial role in the folding, activation and transport of Furin, and a mature chain (residues 108-794) . The mature chain consists of the subtilisin-like catalytic domain, a P domain, which is essential for enzyme activity and the modulation of pH and calcium requirements, and a cytoplasmic domain, which controls the localization and sorting of Furin in the transGolgi network/endosomal system. The purified recombinant human Furin (residues 108-715) corresponds to the mature enzyme terminated before the transmembrane domain.

Synonyms

FURIN; FUR; PACE; SPC1; PCSK3

NCBI Gene ID

5045

UniProt

P09958

Accession Number

NP_002560.1

Accession Number mRNA

NM_002569.2

Chromosomal Location

15q26.1

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human Furin

Clone

(#6E10)

Applications

WB, FC

Purification Method

Protein G chromatography

Assay Protocol

Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.

Host or Source

Mouse

Isotype

IgG2

Alternative Products

Catalog	Name
abx100011-01	Furin (FURIN) Antibody
abx616818	Furin (FURIN) Peptide
MBS7015367-01	Recombinant Mouse Furin (Furin)
MBS7015366-01	Recombinant Human Furin (FURIN)
abx315737-01	Furin (FURIN) Antibody (Biotin)
abx066703-01	Human Furin (FURIN) Protein
abx653476-01	Rat Furin (FURIN) Protein
abx066704-01	Mouse Furin (FURIN) Protein

Furin

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