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Frizzled-2

CAT: 0209-103-M386Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M386Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Wnt signaling is involved in variety of developmental processes including cell fate determination, cell polarity, tissue patterning and control of cell proliferation. Members of the Frizzled family of proteins serve as receptors for the Wnt signaling pathway. The founding member of this family was identified in Drosophila based on its role in tissue polarity in the adult cuticle and named for the disorganized appearance of bristle hairs on the mutant. Ten mammalian Frizzled genes have been identified to date. The predicted structure of Frizzled proteins is similar among all family members, containing a divergent Nterminal signal peptide, a highly conserved extracellular cysteinerich domain, a variablelength linker region, a sevenpass transmembrane domain, and a variablelength C-terminal tail. One of the most conserved regions of the Frizzled proteins is the extracellular cysteine-rich domain (CRD) which spans approximately 120 AA and contains 10 invariant cysteines. Mouse Frizzled-2 shows 100% amino acid identity to human and rat Frizzled2 in the CRD region. Frizzled2 expression is greater in embryonic than adult tissues, with heart, brain, lung, kidney and gut showing the highest levels.
Synonyms
Fzd2; Fz10; Fzd10; Mfz10; Mfz10a; AL033370; AW456835
NCBI Gene ID
57265
UniProt
Q9JIP6
Accession Number
NP_065256.1
Accession Number mRNA
NM_020510.2
Chromosomal Location
11 E1; 11
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse protein Frizzled 2
Clone
(#7D14)
Applications
WB
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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Alternative Products

CatalogName
216542FZD2 (Frizzled-2, Frizzled 2)
481446FZD2 (Frizzled-2, Frizzled Family Receptor 2)
126979Frizzled 2 (Frizzled Family Receptor 2, Frizzled-2, Fz2, Fz-2, FZD2, FzE2, hFz2)
F6401-09AFrizzled 2 (FZD2)
GTR18913749Frizzled 2 Peptide
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536466-01Frizzled-2 discontinued
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