Follistatin

CAT: 0209-101-M421Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-101-M421Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Follistatin is a secreted protein that binds to ligands of the TGF-β family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone) . In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-β ligands including BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF-β1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Human Follistatin is aa 31-33 kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain.
Synonyms
FST; FS
NCBI Gene ID
10468
UniProt
P19883
Accession Number
NP_006341.1
Accession Number mRNA
NM_006350
Chromosomal Location
5q11.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Follistatin
Clone
(#9D28)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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