Rat Anti-Mouse FGFR-3 Monoclonal Antibody

Rat Anti-Mouse FGFR-3 Monoclonal Antibody

• Description: Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N terminal signal peptide, three immunoglobulin (Ig)like domains, an acid box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine kinase domain.
• Synonyms: Fibroblast growth factor receptor 3, FGFR-3, Heparin-binding growth factor receptor, CD333
• CAS Number: 9007-83-4
• UniProt: Q61851
• Accession Number: NP_001156687.1
• Accession Number mRNA: NM_001359036.1
• Host: Rat
• Origin Species: Mouse
• Target Antigen: Mouse Recombinant protein FGF R3
• Isotype: IgG2
• Clone: (#7M13)
• Validated Applications: N, B
• Purification Method: Protein G chromatography
• Form: Lyophilized
• Buffer: PBS
• Reconstitution: Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.