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FAS Ligand, soluble

CAT: 0209-100-157Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0209-100-157Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fas Ligand (FasL) is a member of the TNF superfamily that is expressed on the cell surface of activated T cells. Binding of FasL to Fas Receptor triggers apoptosis in Fas-bearing cells. FasL has the ability to kill T cells and activated B cells which leads to down-regulation of the immune response. The mechanism of Fas induced apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. Both human and murine sFasL are fully active on human and murine cells. Recombinant human soluble Fas Ligand is a 17.9 kDa protein (175 amino acid residues) comprising the TNF homologous region of FasL plus an eight His-Tag.
Synonyms
FASLG; FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1 S1697
NCBI Gene ID
356
UniProt
P48023
Accession Number
NP_035254
Accession Number mRNA
NM_000639.1
Chromosomal Location
1q23
Reactivity
Human
Cross Reactivity
Mouse, Human
Label
His-Tag
Sequence
HHHHHHHHPS PPPEKKELRK VAHLTGKSNS RSMPLEWEDT YGIVLLSGVK YKKGGLVINE TGLYFVYSKV YFRGQSCNNL PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL GAVFNLTSAD HLYVNVSELS LVNFEESQTF FGLYKL
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
>95% by SDS-PAGE & HPLC analysis
Bioactivity
Determined by it's ability to induce cytotoxicity in Jurkat cells in the absence of any cross-linking. The ED50 for this effect is ≤ 10.0 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg.
Length
156
Form
Lyophilized
Molecular Weight
17.9 kDa
Host or Source
CHO cells

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