Rabbit Anti-Human ESAM Polyclonal Antibody
CAT:
209-102-PA42AG
Size:
50 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Rabbit Anti-Human ESAM Polyclonal Antibody
- Description: Endothelial cell-selective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules. Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. The extracellular region contains one V type and one C2 type Ig domain and is involved in homophilic adhesion. In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI. The extracellular region of human ESAM shows 90%, 74%, 69% and 67% aa identity with monkey, canine, mouse and rat extracellular ESAM, respectively. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes, and can be found associated with cellto cell junctions. Whether ESAM is restricted to a particular junctional type is not clear. ESAM deficient mice have no defect in vascularization but do have reduced angiogenic potential. This may be due to a decreased migratory response to FGF-2.
- Synonyms: ESAM; W117m
- CAS Number: 9007-83-4
- NCBI Gene ID: 90952
- UniProt: Q96AP7
- Accession Number: NP_620411.2
- Accession Number mRNA: NM_138961.2
- Gene Location: 11q24.2
- Host: Rabbit
- Origin Species: Human
- Species Reactivity: Human
- Target Antigen: Recombinant Human ESAM (RT #300-057)
- Clone: Rabbit IgG
- Validated Applications: WB, FC
- Purification Method: Antigen-affinity purified
- Detection Range: Western Blot: Use 2-5 µg/ml
- Form: Lyophilized
- Buffer: PBS
- Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
- Shipping Conditions: Room Temperature
- Storage Conditions: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.