ESAM

CAT: 0209-102-PA42AGSize: 50 µgDry Ice: NoHazardous: No
CAT#:0209-102-PA42AGSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Endothelial cell-selective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules. Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. The extracellular region contains one V type and one C2 type Ig domain and is involved in homophilic adhesion. In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI. The extracellular region of human ESAM shows 90%, 74%, 69% and 67% aa identity with monkey, canine, mouse and rat extracellular ESAM, respectively. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes, and can be found associated with cellto cell junctions. Whether ESAM is restricted to a particular junctional type is not clear. ESAM deficient mice have no defect in vascularization but do have reduced angiogenic potential. This may be due to a decreased migratory response to FGF-2.
Synonyms
ESAM; W117m
NCBI Gene ID
90952
UniProt
Q96AP7
Accession Number
NP_620411.2
Accession Number mRNA
NM_138961.2
Chromosomal Location
11q24.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human ESAM (RT #300-057)
Clone
Rabbit IgG
Applications
WB, FC
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
Western Blot: Use 2-5 µg/ml
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Host or Source
Rabbit

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