Epiregulin

CAT: 0209-100-336Size: 25 µgDry Ice: NoHazardous: No

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CAT#:0209-100-336Size:25 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence. Recombinant human Epiregulin is a 5.6 kDa monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence.

Synonyms

EREG; ER

NCBI Gene ID

2069

UniProt

O14944

Accession Number

NP_001423

Accession Number mRNA

NM_001432

Chromosomal Location

4q13.3

Reactivity

Human

Cross Reactivity

Mouse

Sequence

MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

98% by SDS-PAGE & HPLC analyses

Bioactivity

The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105units/mg.

Length

Form

Lyophilized

Molecular Weight

5.6 kDa

Host or Source

E. coli

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Epiregulin

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