Endostatin

• Description:

  Endostatin is a naturally occurring 20 kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant human Endostatin is a 20.2 kDa protein consisting 184 amino acid residues.

• Synonyms:

  COL18A1; KS; KNO; KNO1

• NCBI Gene ID:

  80781

• UniProt:

  P39060

• Accession Number:

  NP_085059

• Accession Number mRNA:

  NM_030582

• Chromosomal Location:

  21q22.3

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Measured by its ability to inhibit HUVEC migration.

• Length:

  184

• Form:

  Lyophilized

• Molecular Weight:

  20.2 kDa

• Host or Source:

  E. coli