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Endomucin

CAT: 0209-S01-M64Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0209-S01-M64Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Endomucin (endothelial sialomucin; also Endomucin-1/2 and Mucin-14) is an 80 - 120 kDa glycoprotein member of the Endomucin family of proteins. It is expressed on endothelial cells and depending upon its glycosylation pattern, can serve as either a pro- or anti-adhesive molecule. Mouse Endomucin precursor is 261 amino acids in length. It is type I transmembrane protein that contains a 170 aa extracellular domain (ECD) (aa 21 - 190) and a 50 aa cytoplasmic region. Three splice variants exist in the ECD. One shows a deletion of aa 91 - 141, a second shows a one aa substitution for aa 91 - 129, and a third shows a one aa substitution for aa 129 - 142. Over aa 21 - 90, mouse Endomucin shares 60% and 30% aa identity with rat and human Endomucin, respectively. The sequence corresponds to Glu20 to Ser190. A 6x His-tag is fused to the C-terminal end of the recombinant mouse soluble Endomucin.
Synonyms
Endomucin-1/2, Mucin-14, Muc-14
NCBI Gene ID
59308
UniProt
Q9R0H2
Accession Number
NP_001156994.1
Accession Number mRNA
NM_001163522.1
Chromosomal Location
3 G3; 3
Reactivity
Mouse
Cross Reactivity
Mouse
Label
His-Tag
Sequence
EDGKDVQNDSIPTPAETSTTKASVTIPGIVSVTNPNKPADGTPPEGTTKSDVSQTSLVTTINSLTTPKHEVGTTTEGPLRNESSTMKITVPNTPTSNANSTLPGSQNKTENQSSIRTTEISVTTQLLDALPKITATSSASLTTAHTMSLLQDTEDRKIATTPSTTPSYSSTRHHHHHH
Assay Protocol
The lyophilized mouse sEndomucin is soluble in water and most aqueous buffers; it should be reconstituted in water or PBS to a concentration of not lower than 100µg/ml.
Purity
> 95% by SDS-PAGE
Bioactivity
Data not available.
Length
178
Form
Lyophilized
Buffer
10mM NaP, pH 7.0
Reconstitution
Water
Molecular Weight
18.78 kDa
Storage Conditions
The material is stable for greater than six months at -20° C to -70° C. After the first thawing it is recommended to aliquote the material, because repeated freeze-thaw cycles will decrease the activity.
Host or Source
E. coli
N Terminal Sequence
EDGKDVQND

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