Dtk (Tyro3)

CAT: 0209-103-M186Size: 100 µgDry Ice: NoHazardous: No

1 / 1

CAT#:0209-103-M186Size:100 µg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk) constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anti-coagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.

Synonyms

Tyro3; Brt; Dtk; Rse; Sky; Tif; Etk-2; AI323366

NCBI Gene ID

22174

UniProt

P55144

Accession Number

NP_062265.2

Accession Number mRNA

NM_019392.2

Chromosomal Location

2 F; 2 67.1 cM

Reactivity

Anti-Mouse

Cross Reactivity

Mouse

Target Antigen

Recombinant mouse Dtk extracellular domain

Clone

(#9J17)

Applications

WB, IHC (P)

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Rat

Isotype

IgG1

Alternative Products

Catalog	Name
529410-01	TYRO3
494959	TYRO3 (Tyrosine-Protein Kinase Receptor TYRO3, TYRO3 Protein Tyrosine Kinase)
030708	TYRO3 (Tyrosine-protein kinase receptor TYRO3)
FY12193	TYRO3 Antibody / TYRO3 protein tyrosine kinase
10R-6198	TYRO3 antibody
030707	Tyro3 discontinued
580501-01	TYRO3 (Biotin)
32-13012-10	TYRO3 Mouse
sc-81160	Tyro3 (1C11E8)
GTR18904410-01	TYRO3 peptide

Dtk (Tyro3)

Alternative Products

Popular Products